Generation of an integrationfree induced pluripotent stem cell line pumchi001a from a patient with familial partial lipodystrophy type 2 fpld2 carrying a heterozygous p. Unipotent stem cells form only one type of specialized cell type. Here, we demonstrate the generation of ips cells from adult human dermal fibroblasts with the same four factors. A common fate for multipotent stem cells is to remain quiescent without dividing or differentiating, thus maintaining its place in the stem cell. Yet, many fundamental questions regarding the specific roles of stem cell in cancer progression and therapy remain elusive, impeding the effective clinical translation of stem cell. Stem cell research holds tremendous promise for the development of novel therapies for many serious diseases and injuries. Stem cell basics last modified on april 08, 2015 about this document this primer on stem cells is intended for anyone who wishes to learn more about the biological properties of stem cells, the important questions about stem cells that are the focus of scientific research, and the potential use of stem cells. The journal publishes key, wellcontrolled advances in stem cell clinical trials and mechanismbased manuscripts with definitive conclusions. Blood and marrow stem cell transplantation guide i 3 part 1 understanding stem cell transplantation for thousands of people with blood cancers, stem cell transplantation sct is. Stem cell research vol 22, pages 188 july 2017 sciencedirect. Building on success of its awardwinning preceding edition, the second edition features new chapters on embryonic and ips cells and stem cells. Wed like to understand how you use our websites in order to improve them. Stem cell research is dedicated to publishing highquality manuscripts focusing on the biology and applications of stem cell research.
Introducing cell reports medicine read the first online papers. Human embryonic stem cells journal of cell science. Based on the two defining characteristics of stem cells unlimited selfrenewal and ability to differentiate, they can be described as having four outcomes or fates 3 figure 2. Stem cells have been widely studied in the fields of cancer biology. The journal is dedicated to publish quality articles with an emphasis on basic, translational and clinical research on stem cell. To make hydrogels a more suitable environment for stem cells, fibrinlike and other cell. In recent years, stem cell therapy has become a very promising and advanced scientific research topic.
Updated list of high journal impact factor stem cell journals. The influence of fibroblast growth factor 2 on the senescence of human adiposederived mesenchymal stem cells during longterm culture. Mesenchymal stem cellderived extracellular vesicles for the treatment of acute respiratory distress syndrome aswin abraham anna krasnodembskaya wellcomewolfson institute for experimental medicine, queens university of belfast, belfast, united kingdom correspondence anna krasnodembskaya, phd, wellcomewolfson institute for experimental medicine. Stem cells have great potential in tissue regeneration and repair but much.
Singh maulana azad medical college and associated lok nayak and g. Most downloaded stem cell research articles elsevier. Stem cell therapies hold considerable promise, but their clinical application is predicated on the development of appropriate delivery platforms. Evidence suggests that msc evs demonstrate potent protective effects mediated through a variety of mechanisms related to the transfer of evs cargo to the recipient cells. Helen blau on stem cells in the treatment of disease. Generation of an induced pluripotent stem cell line shcdni001a from a oneyearold chinese girl with mitochondrial dna depletion syndrome. While stem cell based treatments have been established as a clinical standard of care for some conditions, such as hematopoietic stem cell transplants for leukemia and epithelial stem cell. The article is accompanied by a slide show, an illustrated glossary, and an audio interview with one of the authors. Read our pledge formalizing our commitment to strong representation of women scientists on our journal advisory boards.
Pdf as scientists position themselves in translating the therapeutic potential of stem cells from laboratory to clinical applications, publishing. Stem cells is read and written by clinical and basic scientists whose expertise encompasses the rapidly expanding fields of stem and progenitor cell biology. Stem cells focuses primarily on the functional and mechanistic aspects of stem cell biology and the potential of different types of stem cells for therapeutic applications. Generation of the human induced pluripotent stem cell line ukwnli002a from dermal fibroblasts of a woman with a heterozygous c. Receive an update when the latest issues in this journal are published. The spectacular progress in the field of stem cell research has laid the foundation for cell based therapies of disease which cannot be cured by conventional. Citescore values are based on citation counts in a given year. Stem cell therapy is emerging as a potentially revolution ary new way to treat. Pdf stem cell therapy in treatment of different diseases. Most downloaded stem cell research articles the most downloaded articles from stem cell research in the last 90 days.
Candidate es and eg cell lines from the human blastocyst and embryonic gonad can differentiate into multiple types of somatic cell. Multipotentstem cells can form multiple types of cells. Human ips cells were similar to human embryonic stem. As in animals, stem cells reside in stem cell niches, which produce signals that regulate the balance between selfrenewal and the generation of daughter cells that differentiate into new. Cell sources, characteristics, differentiation and therapeutic applications are discussed. Welldefined synthetic hydrogels have emerged as promising vehicles for stem cell delivery. The genesis of stem cells is followed by laboratory steps of controlled stem cell. With a focus on stem cells of all tissue types and their potential therapeutic applications, the journal. The development of treatment methods has evoked great expectations. The study of these mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self. Exosome secreted by msc reduces myocardial ischemiareperfusion injury open archive.
Stem cells wiley online library stem cells journals. Pdf the proliferation and differentiation of stem cell journals. Introduction to stem cell therapy pubmed central pmc. Embryonic stem es cells are cells derived from the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent. Allogeneic manufacturing of stem cells for therapies. Stem cells and development is globally recognized as the trusted source for critical, even controversial coverage of emerging hypotheses and novel findings. Generation of the induced pluripotent stem cell line uhomi001a from a patient with mutations in ccdc40 gene causing primary ciliary dyskinesia pcd engi ahmed, caroline sansac, mathieu fieldes, anne bergougnoux. Stem cell research vol 33, pages 1278 december 2018. Indian journal of human genetics januaryapril 2006 volume 12 issue 1. Submissions to stem cell research, may cover all aspects of stem cells, including embryonic stem cells, tissuespecific stem cells, cancer stem cells. Rapid advances in the isolation of multipotent progenitor cells, routinely called mesenchymal stromal stem cells mscs, from various human tissues and organs have provided impetus to the field of cell. Publisher of over 50 scientific journals across the life, physical, earth, and health sciences, both independently and in partnership with scientific societies including cell, neuron, immunity, current biology, ajhg, and the trends journals. Stem cells applications in regenerative medicine and disease. Stem cell therapy in treatment of different dis eases 84 acta medica iranica, vol.
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